UCBL

University Claude Bernard Lyon 1

Institution :

University Claude Bernard Lyon 1 (UCBL) is a multidisciplinary university in the primary fields of physics, chemistry, technical and material sciences, medicine and pharmacy.
UCBL has been working for decades on electrochemical and optical biosensors technologies and biomolecules immobilization strategies. Numerous publications and book chapters on these subjects were published by the group between the early 70’s and the late 90’s.
During the last 10 years, innovative works led to the publication or patenting (WO2005039751, WO2005054858, FR2867180) of technologies such as electro-addressing of diazonium-protein adducts and soft lithography material functionalization with biomolecules.
UCBL has shown its European networking and scientific exchange abilities within different terminated (FP5: FAIR-CT95-109; MENDOS: n. QLRT-2001-02323 and FP6: NANOSPAD: STREP 016610; CAREMAN: IP 017333) or still running European programs (STREP - FP7-SEC-2010-1: BONAS). Besides, UCBL has been coordinating a FP7 Marie Curie IEF-2007 project (1CellMicroprobe) involving a Canadian partner (McGill University) and itself for a 30 months period duration. The team was also an active expert in the FP6 Nano2Life Network of Excellence.
The main activity of the laboratory concerns the study of enzymes and biomolecules in structured media. The biospecific molecular recognition, a unique property of some biomolecules (enzymes, antibodies, nucleic acids, lectins…), is exploited to develop sensing layers associated with signal transduction systems for the design of biosensors, i.e. enzyme electrodes, fiberoptic biosensors, immunosensors, sensorchips…

Significant infrastructure :

Piezoelectric spotters (SCIENION S1 and S3)
Liquid handling automate (TECAN EVO 75)
3D printers (OBJET PRO; B9 stereolithography; TOBECA PLA based systems; In house developed BIOPRINTER)
high resolutions cameras (HAMAMATSU -60°C cooled camera; FUJI -30°C cooled camera)

Role in the project:

UCBL will be in charge of the coordination of the project. The UCBL is specialised in the development of new diagnostic tool concepts and applications and will then be in charge of the Patho-Stick and Patho-Doc design and prototyping using various 3D printing and adhesive lamination technologies.

Team:

Dr. Christophe Marquette, Research Director at ICBMS0, head of the Biochip group, will be the Coordinator of FAPIC.
Dr. C.A. Marquette, received the Doctorat de spécialité in Biochemistry (1999) from the Université Claude Bernard-Lyon 1. He is presently Research Director at the Centre National de la Recherche Scientifique (CNRS) at the UCBL and is in charge of the development of optical biochips and micro-arrays based on luminescent reactions. Since 1998 author or co-author of 101 articles, 12 book chapters and 6 international patents.
He has shown its European networking and scientific exchange abilities within different terminated (FP5: FAIR-CT95-109; MENDOS: n. QLRT-2001-02323 and FP6: NANOSPAD: STREP 016610; CAREMAN: IP 017333) or still running European programs (STREP - FP7-SEC-2010-1: BONAS).
Besides, he has been coordinating a FP7 Marie Curie IEF-2007 project (1CellMicroprobe) involving a Canadian partner (McGill University) and itself for a 30 months period duration. The coordinator was also an active expert in the FP6 Nano2Life Network of Excellence. He also demonstrate its national networking capacities through terminated (ANR PNANO 2005: CAPTCODE) or still running (ANR BioTecS 2008: APTAPROBE; ANR – BiotecS 2010: HiFi-assays) national programs.

Illustrations of relevant activities